Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface
antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen …

Recent advances in the understanding of immune function and the interactions with tumour
cells have led to the development of various cancer immunotherapies and strategies for …

Dendritic cell (DC) vaccines are used for cancer and infectious diseases, albeit with limited
efficacy. Modulating the formation of DC–T‐cell synapses may greatly increase their efficacy …

Ovarian malignancies remain the leading cause of death in female gynecological tumors.
More than 70% of patients are diagnosed with advanced stage with extensive metastatic …

Fifty-two years have passed since President Nixon launched the “War on Cancer”. Despite
unparalleled efforts and funds allocated worldwide, the outlined goals were not achieved …

Globally, as a leading agent of acute respiratory tract infections in children< 5 years of age
and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As …

Immunotherapy has become a prominent strategy for the treatment of cancer. A method that
improves the immune system's ability to attack a tumor (Enhances antigen binding) …

During tumor evolution, cancer cells use the tumor‐stroma crosstalk to reorganize the
microenvironment for maximum robustness of the tumor. The success of immune checkpoint …

T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical
step in the development of proper immune responses to infection and inflammation. This …

It is becoming increasingly clear that communication between cells is carried out not only by
the signaling molecules themselves, but also by many contextual and positional cues that …