Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …

Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and
a significant obstacle to improving patients' health and lives. Mitochondria are core …

Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

The hexosamine biosynthetic pathway (HBP) produces uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) to facilitate O-linked GlcNAc (O-GlcNAc) protein …

Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …

As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a
variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and …

In the last few years, more and more scientists have suggested and confirmed that
epigenetic regulators are tightly connected and form a comprehensive network of regulatory …

Background Doxorubicin (DOX) is among the most widely employed antitumor agents,
although its clinical applications have been largely hindered by severe cardiotoxicity. Earlier …