[HTML][HTML] All roads lead to Rome: different molecular players converge to common toxic pathways in neurodegeneration

S Argueti-Ostrovsky, L Alfahel, J Kahn, A Israelson - Cells, 2021 - mdpi.com
Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …

[HTML][HTML] The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases

C Zhang, X Kan, B Zhang, H Ni, J Shao - Molecular Brain, 2022 - Springer
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the
immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such …

Early clues and molecular mechanism involved in neurodegenerative diseases induced in immature mice by combined exposure to polypropylene microplastics and …

G Yang, C Gong, X Zheng, F Hu, J Liu, T Wang… - Environmental …, 2023 - Elsevier
Studies have shown that exposure to either microplastics (MPs) or di-(2-ethylhexyl) phthalic
acid (DEHP) alone can cause neurotoxicity in animals, but it remains uncertain whether and …

[HTML][HTML] Extracellular HSPs: the potential target for human disease therapy

DY Li, S Liang, JH Wen, JX Tang, SL Deng, YX Liu - Molecules, 2022 - mdpi.com
Heat shock proteins (HSPs) are highly conserved stress proteins known as molecular
chaperones, which are considered to be cytoplasmic proteins with functions restricted to the …

[HTML][HTML] Protein interactome of amyloid-β as a therapeutic target

VF Lazarev, EA Dutysheva, IE Kanunikov, IV Guzhova… - Pharmaceuticals, 2023 - mdpi.com
The amyloid concept of Alzheimer's disease (AD) assumes the β-amyloid peptide (Aβ) as
the main pathogenic factor, which injures neural and other brain cells, causing their …

[HTML][HTML] Closest horizons of Hsp70 engagement to manage neurodegeneration

AA Venediktov, OY Bushueva… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Our review seeks to elucidate the current state-of-the-art in studies of 70-kilodalton-weighed
heat shock proteins (Hsp70) in neurodegenerative diseases (NDs). The family has already …

[HTML][HTML] Manipulation of HSP70-SOD1 expression modulates SH-SY5Y differentiation and susceptibility to oxidative stress-dependent cell damage: involvement in …

M Scordino, M Frinchi, G Urone, D Nuzzo, G Mudò… - Antioxidants, 2023 - mdpi.com
The differentiation of neural progenitors is a complex process that integrates different signals
to drive transcriptional changes, which mediate metabolic, electrophysiological, and …

[HTML][HTML] Heat shock proteins adaptive responses to environmental stressors and implications in health management of decapods

K Mengal, G Kor, P Kozák, H Niksirat - Aquaculture Reports, 2023 - Elsevier
Heat shock proteins (HSPs) are highly conserved, cytoprotective proteins, the best know
function of which is to facilitate the proper folding of nascent proteins. Environmental …

[HTML][HTML] Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration

F Biagioni, M Ferrucci, G Lazzeri, M Scioli… - International Journal of …, 2024 - mdpi.com
The present investigation was designed based on the evidence that, in neurodegenerative
disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the …

Identification and prioritization of PET neuroimaging targets for microglial phenotypes associated with microglial activity in Alzheimer's disease

ND Bartolo, N Mortimer, MA Manter… - ACS Chemical …, 2022 - ACS Publications
Activation of microglial cells accompanies the progression of many neurodegenerative
disorders, including Alzheimer's disease (AD). Development of molecular imaging tools …