Stress is defined as an adverse condition that disturbs the homeostasis of the body and
activates adaptation responses. Among the many pathways and mediators involved …

The melanocortin system provides a conceptual blueprint for the central control of energetic
state. Defined by four principal molecular components—two antagonistically acting ligands …

Binge alcohol drinking is a tremendous public health problem because it leads to the
development of numerous pathologies, including alcohol abuse and anxiety. It is thought to …

Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

Children with neurofibromatosis type 1 (NF1) are increasingly recognized as having a high
prevalence of social difficulties and autism spectrum disorders (ASDs). We demonstrated a …

While anxiety disorders are the brain disorders with the highest prevalence and constitute a
major burden for society, a considerable number of affected people are still treated …

Efficient control of feeding behavior requires the coordinated adjustment of complex
motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic …

Resilience to traumatic stress is a complex psychobiological process that protects
individuals from developing posttraumatic stress disorder (PTSD) or other untoward …

Posttraumatic stress disorder (PTSD) is a trauma-evoked syndrome, with variable
prevalence within the human population due to individual differences in coping and …

Neuropeptide Y (NPY) signaling regulation of corticolimbic communication is known to
modulate binge-like ethanol consumption in rodents. In this work we sought to assess the …