Viral oncology: molecular biology and pathogenesis

UN Mui, CT Haley, SK Tyring - Journal of clinical medicine, 2017 - mdpi.com
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of
the world's population harbors at least one of these oncoviruses, but only a small proportion …

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

M Matsuoka, KT Jeang - Nature Reviews Cancer, 2007 - nature.com
It has been 30 years since a'new'leukaemia termed adult T-cell leukaemia (ATL) was
described in Japan, and more than 25 years since the isolation of the retrovirus, human T …

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

N Gillet, A Florins, M Boxus, C Burteau, A Nigro… - Retrovirology, 2007 - Springer
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was
considered to be the first reported case of bovine leukemia. The etiological agent of this …

Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV

SM Rodríguez, A Florins, N Gillet, A De Brogniez… - Viruses, 2011 - mdpi.com
Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus
type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1

J Arnold, B Yamamoto, M Li, AJ Phipps, I Younis… - Blood, 2006 - ashpublications.org
Natural antisense viral transcripts have been recognized in retroviruses, including human T-
cell leukemia virus type 1 (HTLV-1), HIV-1, and feline immunodeficiency virus (FIV), and …

Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2

G Feuer, PL Green - Oncogene, 2005 - nature.com
Abstract HTLV-1 and HTLV-2 are highly related complex retroviruses that have been studied
intensely for nearly three decades because of their association with neoplasia …

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity

I Azran, Y Schavinsky-Khrapunsky, M Aboud - Retrovirology, 2004 - Springer
HTLV-1 is the etiological agent of adult T-cell leukemia (ATL), the neurological syndrome
TSP/HAM and certain other clinical disorders. The viral Tax protein is considered to play a …

HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection

B Asquith, Y Zhang, AJ Mosley… - Proceedings of the …, 2007 - National Acad Sciences
Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus.
Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell …