Ceramides are composed of a sphingosine and a single fatty acid connected by an amide
linkage. As one of the major classes of biologically active lipids, ceramides and their …

Sphingolipids, as members of the large lipid family, are important components of plasma
membrane. Sphingolipids participate in biological signal transduction to regulate various …

BACKGROUND Sphingolipids (SPs) are ubiquitous, structurally diverse molecules that
include ceramides, sphingomyelins (SMs), and sphingosines. They are involved in various …

Background Animal studies suggest vital roles of sphingolipids, especially ceramides, in the
pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell …

Background Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder
associated with multiple metabolic conditions including obesity, insulin resistance, and …

Introduction Sphingolipids are a diverse class of lipids with various roles in cell functions
and subclasses such as ceramides have been associated with cardiovascular diseases …

Here were report the combination of biocompatible click chemistry of ω-azidosphinganine
with fluorescence microscopy and mass spectrometry as a powerful tool to elaborate the …

Chronic kidney disease (CKD) is by far the most prevalent disease in the world and is now a
major global public health problem because of the increase in diabetes, hypertension and …

Scientific Background: Sphingolipids are a highly diverse group of lipids with respect to
physicochemical properties controlling either structure, distribution, or function, all of them …

Background Diabetes has become popular and has become one of the most important
global health care challenges. Patients with diabetes have a high incidence of skin …