Detecting RNA modifications in the epitranscriptome: predict and validate
RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …
gene expression, and are attracting a comparable degree of research interest to DNA and …
The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has
opened the possibility that sperm may function by delivering additional paternal information …
opened the possibility that sperm may function by delivering additional paternal information …
The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark
L Trixl, A Lusser - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …
amount to over a hundred. The vast majority of these modifications was observed in the two …
[HTML][HTML] Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense
X Xia - Molecular biology and evolution, 2020 - academic.oup.com
Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …
[HTML][HTML] Epigenetic responses and the developmental origins of health and disease
D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …
successful postnatal life. Based on the stressors during gestation, the pregnant female …
[HTML][HTML] The role of RNA m5C modification in cancer metastasis
Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …
RNA nucleotide methylation: 2021 update
Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
Epigenetic effects of metformin: from molecular mechanisms to clinical implications
SC Bridgeman, GC Ellison, PE Melton… - Diabetes, Obesity …, 2018 - Wiley Online Library
There is a growing body of evidence that links epigenetic modifications to type 2 diabetes.
Researchers have more recently investigated effects of commonly used medications …
Researchers have more recently investigated effects of commonly used medications …