Copper is an essential cofactor of various enzymes, but free copper is highly toxic to living
cells. To maintain cellular metabolism at different ambient copper concentrations, bacteria …

Recent findings suggest that both host and pathogen manipulate copper content in infected
host niches during infections. In this review, we summarize recent developments that …

Many transcriptional activators act at a distance from core promoter elements and work by
recruiting RNA polymerase through protein-protein interactions. We show here how the …

The interactions between proteins and their specific DNA sequences are the basis of many
cellular processes. Hence, developing methods to build an atomic level picture of these …

Copper is an essential micronutrient that also exerts toxic effects at high concentrations. This
review summarizes the current state of knowledge on copper handling and homeostasis …

Binding and unbinding of transcription regulators at operator sites constitute a primary
mechanism for gene regulation. While many cellular factors are known to regulate their …

CueR (Cu export regulator) is a metalloregulator protein that" senses" Cu (I) ions with very
high affinity, thereby stimulating DNA binding and the transcription activation of two other …

Metalloregulators regulate transcription in response to metal ions. Many studies have
provided insights into how transcription is activated upon metal binding by MerR-family …

Metalloregulators bind and respond to metal ions by regulating the transcription of metal
homeostasis genes. Copper efflux regulator (CueR) is a copper‐responsive …

Conspectus Dynamic protein–DNA interactions constitute highly robust cellular machineries
to fulfill cellular functions. A vast number of studies have focused on how DNA-binding …