Virus-like particle vaccines and platforms for vaccine development

M Kheirvari, H Liu, E Tumban - Viruses, 2023 - mdpi.com
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use
of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human …

Phage display—A powerful technique for immunotherapy: 1. Introduction and potential of therapeutic applications

J Bazan, I Całkosiński, A Gamian - Human vaccines & …, 2012 - Taylor & Francis
One of the most effective molecular diversity techniques is phage display. This technology is
based on a direct linkage between phage phenotype and its encapsulated genotype, which …

Virus-like particles for the prevention of human papillomavirus-associated malignancies

JW Wang, RBS Roden - Expert review of vaccines, 2013 - Taylor & Francis
As compared with peptide-or protein-based vaccines, naked DNA vectors and even
traditional attenuated or inactivated virus vaccines, virus-like particles (VLPs) are an …

A cholesterol-lowering VLP vaccine that targets PCSK9

E Crossey, MJA Amar, M Sampson, J Peabody… - Vaccine, 2015 - Elsevier
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protein that controls
cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the low …

Nanoparticle-based adjuvants and delivery systems for modern vaccines

B Filipić, I Pantelić, I Nikolić, D Majhen… - Vaccines, 2023 - mdpi.com
Ever since the development of the first vaccine, vaccination has had the great impact on
global health, leading to the decrease in the burden of numerous infectious diseases …

Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures

P Pushko, P Pumpens, E Grens - Intervirology, 2013 - karger.com
Virus-like particle (VLP) technology is a promising approach for the construction of novel
vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived …

HPV vaccines to prevent cervical cancer and genital warts: an update

C Dochez, JJ Bogers, R Verhelst, H Rees - Vaccine, 2014 - Elsevier
Cervical cancer is an important public health problem worldwide, and especially in
developing countries. The link between cervical cancer and oncogenic human …

Dissolving microneedle delivery of a prophylactic HPV vaccine

S Ray, DM Wirth, OA Ortega-Rivera… - …, 2022 - ACS Publications
Prophylactic vaccines capable of preventing human papillomavirus (HPV) infections are still
inaccessible to a vast majority of the global population due to their high cost and challenges …

Evidence that viral RNAs have evolved for efficient, two-stage packaging

A Borodavka, R Tuma… - Proceedings of the …, 2012 - National Acad Sciences
Genome packaging is an essential step in virus replication and a potential drug target.
Single-stranded RNA viruses have been thought to encapsidate their genomes by gradual …

RG1-VLP and other L2-based, broad-spectrum HPV vaccine candidates

B Huber, JW Wang, RBS Roden… - Journal of Clinical …, 2021 - mdpi.com
Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-
assembled from L1 major-capsid proteins that are remarkably effective prophylactic …