Enhancing the in vitro and in vivo stabilities of polymeric nucleic acid delivery nanosystems
Gene therapy holds great promise for various medical and biomedical applications. Nonviral
gene delivery systems formed by cationic polymer and nucleic acids (eg, polyplexes) have …
gene delivery systems formed by cationic polymer and nucleic acids (eg, polyplexes) have …
Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines
S Beg, WH Almalki, F Khatoon, KS Alharbi… - Drug Discovery …, 2021 - Elsevier
Highlights•Cancer vaccines present new therapeutic interventions for treatment.•Use of
functional lipids and polymers provides enhanced deliverability.•Significant momentum has …
functional lipids and polymers provides enhanced deliverability.•Significant momentum has …
Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry
Modification with polyethylene glycol (PEG) is currently considered an important strategy for
anti-cancer drug delivery, because PEGylated-nanoparticles would be effectively delivered …
anti-cancer drug delivery, because PEGylated-nanoparticles would be effectively delivered …
Advancing nonviral gene delivery: lipid-and surfactant-based nanoparticle design strategies
Gene therapy is a technique utilized to treat diseases caused by missing, defective or
overexpressing genes. Although viral vectors transfect cells efficiently, risks associated with …
overexpressing genes. Although viral vectors transfect cells efficiently, risks associated with …
Lipid-based vectors for therapeutic mRNA-based anti-cancer vaccines
ML Guevara, S Persano… - Current Pharmaceutical …, 2019 - ingentaconnect.com
Cancer vaccines have been widely explored as a key tool for effective cancer
immunotherapy. Despite a convincing rationale behind cancer vaccines, extensive past …
immunotherapy. Despite a convincing rationale behind cancer vaccines, extensive past …
Self-assembly of poly (allylamine)/siRNA nanoparticles, their intracellular fate and siRNA delivery
D Di Silvio, M Martínez-Moro, C Salvador… - Journal of colloid and …, 2019 - Elsevier
Silencing RNA (siRNA) technologies attract significant interest as a therapeutic tool for a
large number of diseases. However, the medical translation of this technology is hampered …
large number of diseases. However, the medical translation of this technology is hampered …
Lipid substitution on low molecular weight (0.6–2.0 kDa) polyethylenimine leads to a higher zeta potential of plasmid DNA and enhances transgene expression
KCR Bahadur, B Landry, HM Aliabadi, A Lavasanifar… - Acta biomaterialia, 2011 - Elsevier
Cationic polymers are desirable gene carriers because of their better safety profiles than
viral delivery systems. Low molecular weight (MW) polymers are particularly attractive, since …
viral delivery systems. Low molecular weight (MW) polymers are particularly attractive, since …
Structural stability and increase in size rationalize the efficiency of lipoplexes in serum
We have investigated the effect of serum on nanometric structure, size, surface potential,
DNA-binding capacity, and transfection efficiency of DDAB-DOPE/DNA and DC-Chol …
DNA-binding capacity, and transfection efficiency of DDAB-DOPE/DNA and DC-Chol …
[图书][B] Nanotherapeutics: from laboratory to clinic
EH Chowdhury - 2016 - books.google.com
The emergence of nanotherapeutics is attributable to the integration of nanotechnology,
recombinant DNA technology, and synthetic organic chemistry with medicine for treating …
recombinant DNA technology, and synthetic organic chemistry with medicine for treating …
[HTML][HTML] Fluorescence methods for lipoplex characterization
Since the first reported transfection studies using cationic liposomes in 1987, significant
advances have been made on the understanding of the physical properties of DNA/cationic …
advances have been made on the understanding of the physical properties of DNA/cationic …