[HTML][HTML] A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos
Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer
of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural …
of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural …
Overview and update on methods for cargo loading into extracellular vesicles
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …
However, several factors limit the therapeutic potential of these drugs, such as drug …
M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3
Y Xiong, L Chen, C Yan, W Zhou, T Yu, Y Sun… - Journal of …, 2020 - Springer
Background Osteoblast differentiation is a vital process for fracture healing, and exosomes
are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely …
are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely …
Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases
Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …
Extracellular vesicle nanoarchitectonics for novel drug delivery applications
Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)
physiological processes and transport biomolecules to recipient cells. EVs possess the …
physiological processes and transport biomolecules to recipient cells. EVs possess the …
[HTML][HTML] Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model
Z Li, P Zhao, Y Zhang, J Wang, C Wang, Y Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Familial hypercholesterolemia (FH), with high LDL (low-density lipoprotein) cholesterol
levels, is due to inherited mutations in genes, such as low-density lipoprotein receptor …
levels, is due to inherited mutations in genes, such as low-density lipoprotein receptor …
Extracellular vesicles and immunity: at the crossroads of cell communication
Extracellular vesicles (EVs), comprising exosomes and microvesicles, are small
membranous structures secreted by nearly all cell types. They have emerged as crucial …
membranous structures secreted by nearly all cell types. They have emerged as crucial …
Exosomes as carriers for drug delivery in cancer therapy
W Zeng, Z Wen, H Chen, Y Duan - Pharmaceutical Research, 2023 - Springer
Exosomes are extracellular vesicles secreted by cells with a particle size of 30–150 nm in
diameter. Exosomes can be used as natural drug carriers. The treatment of cancer with drug …
diameter. Exosomes can be used as natural drug carriers. The treatment of cancer with drug …
[HTML][HTML] Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment
Z Yang, P Ji, Z Li, R Zhang, M Wei, Y Yang, L Yuan… - Theranostics, 2023 - ncbi.nlm.nih.gov
Extracellular vesicle (EV)-based low-density lipoprotein receptor (Ldlr) mRNA delivery
showed excellent therapeutic effects in treating familial hypercholesterolemia (FH) …
showed excellent therapeutic effects in treating familial hypercholesterolemia (FH) …
Extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges
A Oshchepkova, M Zenkova, V Vlassov - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …
cells of various origins. They contain different biological cargoes, protecting them from …