Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Ecologically mediated selection against hybrids, caused by hybrid phenotypes fitting poorly
into available niches, is typically viewed as distinct from selection caused by epistatic …

Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Now updated for its second edition, Population Genetics is the classic, accessible
introduction to the concepts of population genetics. Combining traditional conceptual …

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary
biology. It is difficult even when adaptive mutations are known because it is hard to …

We develop a conceptual framework for studying collective adaptation in complex socio-
cognitive systems, driven by dynamic interactions of social integration strategies, social …

A longstanding goal of biology is to identify the key genes and species that critically impact
evolution, ecology, and health. Network analysis has revealed keystone species that …

Studies of protein fitness landscapes reveal biophysical constraints guiding protein
evolution and empower prediction of functional proteins. However, generalisation of these …

Fitness landscapes are often described in terms of 'peaks' and 'valleys', indicating an
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …

Fitness landscape theory predicts that rugged landscapes with multiple peaks impair
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …