Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β (Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

Iron is a crucial element for mammalian cells, considering its intervention in several
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …

Non-apoptotic cell death such as ferroptosis and pyroptosis has shed new light on cancer
treatment, whereas combinational therapy using both these mechanisms has not yet been …

Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

We have previously demonstrated that iron overload in hepatic reticuloendothelial system
cells (RES) is associated with severe nonalcoholic steatohepatitis (NASH) and advanced …

The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease
and stroke, is increasing. An increasing number of studies have correlated these diseases …

Iron accumulation in microglia has been observed in Alzheimer's disease and other
neurodegenerative disorders and is thought to contribute to disease progression through …