Hybrid modeling in bioprocess dynamics: Structural variabilities, implementation strategies, and practical challenges

B Mahanty - Biotechnology and Bioengineering, 2023 - Wiley Online Library
Hybrid modeling, with an appropriate blend of the mechanistic and data‐driven framework,
is increasingly being adopted in bioprocess modeling, model‐based experimental design …

Exploring the potential of time-series transformers for process modeling and control in chemical systems: an inevitable paradigm shift?

N Sitapure, JSI Kwon - Chemical Engineering Research and Design, 2023 - Elsevier
The last two years have seen groundbreaking advances in natural language processing
(NLP) with the advent of applications like ChatGPT, Codex, and ChatSonic. This revolution …

CrystalGPT: Enhancing system-to-system transferability in crystallization prediction and control using time-series-transformers

N Sitapure, JSI Kwon - Computers & Chemical Engineering, 2023 - Elsevier
For prediction and real-time control tasks, machine-learning (ML)-based digital twins are
frequently employed. However, while these models are typically accurate, they are custom …

Deep hybrid model‐based predictive control with guarantees on domain of applicability

MSF Bangi, JSI Kwon - AIChE Journal, 2023 - Wiley Online Library
A hybrid model integrates a first‐principles model with a data‐driven model which predicts
certain unknown dynamics of the process, resulting in higher accuracy than first‐principles …

Introducing hybrid modeling with time-series-transformers: A comparative study of series and parallel approach in batch crystallization

N Sitapure, J Sang-Il Kwon - Industrial & Engineering Chemistry …, 2023 - ACS Publications
Given the hesitance surrounding the direct implementation of black-box tools due to safety
and operational concerns, fully data-driven deep-neural-network (DNN)-based digital twins …

Achieving optimal paper properties: A layered multiscale kMC and LSTM-ANN-based control approach for kraft pulping

P Shah, HK Choi, JSI Kwon - Processes, 2023 - mdpi.com
The growing demand for various types of paper highlights the importance of optimizing the
kraft pulping process to achieve desired paper properties. This work proposes a novel …

From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

R Agharafeie, JRC Ramos, JM Mendes, R Oliveira - Fermentation, 2023 - mdpi.com
Deep learning is emerging in many industrial sectors in hand with big data analytics to
streamline production. In the biomanufacturing sector, big data infrastructure is lagging …

An adaptive data-driven approach for two-timescale dynamics prediction and remaining useful life estimation of Li-ion batteries

B Bhadriraju, JSI Kwon, F Khan - Computers & Chemical Engineering, 2023 - Elsevier
During the multi-cycle operation of a Li-ion battery, its process dynamics evolve in two
distinct timescales: slow degradation dynamics over multiple cycles and fast cycling …

Advancing biomass fractionation with real-time prediction of lignin content and MWd: A kMC-based multiscale model for optimized lignin extraction

J Kim, S Pahari, J Ryu, M Zhang, Q Yang… - Chemical Engineering …, 2024 - Elsevier
Recently, lignin has garnered significant research attention due to its abundance in nature.
However, lignin is viewed as a recalcitrance factor as it impedes the overall biomass …

Unveiling latent chemical mechanisms: Hybrid modeling for estimating spatiotemporally varying parameters in moving boundary problems

S Pahari, P Shah, J Sang-Il Kwon - Industrial & Engineering …, 2024 - ACS Publications
Hybrid modeling has gained substantial recognition due to its capacity to seamlessly
integrate machine learning methodologies while preserving the fundamental physical …