Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …

Macroautophagy is an essential cellular pathway mediating the lysosomal degradation of
defective organelles, long-lived proteins and a variety of protein aggregates. Similar to other …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …

Viral pathogens often exploit host cell regulatory and signaling pathways to ensure an
optimal environment for growth and survival. Several studies have suggested that 5 …

Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …