The beneficial effects of statins are the result of their capacity to reduce cholesterol
biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the …

LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

Background Case-control studies have reported that patients with ischemic heart disease
(IHD) have a higher proportion of small, dense LDL particles than do healthy control …

A predominance of small, dense low-density lipoproteins (LDL) has been accepted as an
emerging cardiovascular risk factor by the National Cholesterol Education Program Adult …

The concentration of plasma LDL subfractions is described in four groups of
normocholesterolaemic (total plasma cholesterol< 6.5 mmol/l) male subjects consisting of …

Aim of the present Consensus Statement is to provide a comprehensive and up to-date
document on the pathophysiology, atherogenicity and clinical significance of low density …

OBJECTIVE:: To determine whether large triglyceride-rich lipoproteins, very-low-density
lipoprotein1 (VLDL1), and small, dense low-density lipoprotein (LDL-III), are significantly …

More than decade ago, several cross-sectional studies have reported differences in LDL
particle size, density and composition between coronary heart disease (CHD) patients and …

Coronary heart disease (CHD) is the leading cause of mortality in Western countries[l-5]. A
strong, positive correlation between high levels of plasma total and low density lipoprotein …