Dendritic cells (DCs) occupy a central position in the immune system, orchestrating a wide
repertoire of responses that span from the development of self-tolerance to the elicitation of …

Increasing evidence shows that numerous cancer-testis antigens (CTAs) are uniquely
overexpressed in various types of cancer and most CTAs are oncogenic. Overexpression of …

Undifferentiated and poorly differentiated thyroid tumors are responsible for more than half
of thyroid cancer patient deaths in spite of their low incidence. Conventional treatments do …

Purpose: We evaluated the clinical benefit of an allogeneic melanoma cell lysate (MCL)–
pulsed autologous dendritic cell (DC) vaccine in advanced colorectal cancer patients …

GAGE cancer/testis antigens are frequently expressed in many different types of cancer,
whereas their expression in normal tissues is limited to the germ cells of the immune …

Patients with disseminated colorectal cancer have a poor prognosis. Preliminary studies
have shown encouraging results from vaccines based on dendritic cells. The aim of this …

Introduction: Great advances have been made in screening for and treatment of colorectal
cancer (CRC), but recurrence rates remain high and additional therapies are needed. There …

Introduction. Immunotherapy based on dendritic cell vaccination has exciting perspectives
for treatment of cancer. In order to clarify immunological mechanisms during vaccination it is …

Tumor lysate-pulsed dendritic cell injections were well-tolerated in all patients with no more
than grade 1 injection-related toxicity. Local inflammatory response was mainly …

Cancer-germline antigens are promising targets for cancer immunotherapy, but whether
such therapies will also eliminate the primary tumor stem cell population remains …