The two enantiomers of a compound often have profoundly different biological properties
and thus their liability to racemisation in aqueous solutions is an important piece of …

Racemases and epimerases catalyse changes in the stereochemical configurations of chiral
centres and are of interest as model enzymes and as biotechnological tools. They also …

Palladium-catalyzed cross-couplings remain among the most robust methodologies to form
carbon–carbon and carbon-heteroatom bonds. In particular, carbon–nitrogen (C–N) …

In the absence of any approved dengue-specific treatment, the discovery and development
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …

The racemization of biomolecules in the active site can reduce the biological activity of
drugs, and the mechanism involved in this process is still not fully comprehended. The …

This study aims to investigate the impact of four key factors, namely, temperature, water
source, metal ion, and pH, on the stability of molecular chirality of dihydromyricetin (DMY) …

The main purpose of this work was to discover the way to obtain pure enantiomers of indan-
1-ol. The subject of the study was the ability of the plant enzyme system to reduce the …

Chirality is an academically exciting and interesting topic, as most active ingredients have
chirality. Chiral enantiomers with the same molecular shape show different effects from each …

In a non-chiral environment, the enantiomers of a racemate possess the same physical and
chemical properties. By contrast, metabolic and regulatory processes mediated by biological …

Nitrogen-inversion rates and diffusion coefficients were measured using 1H NMR for 14
drug-like molecules. The slow nitrogen-inversion rates interconverting the enantiomers of …