Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

Increased inflammation in major depressive disorder (MDD) has been associated with low
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …

Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …

Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …

Patients with cancer are at greater risk of developing depression in comparison to the
general population and this is associated with serious adverse effects, such as poorer …

In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have
emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated …

Background Converging evidence suggests that elevated inflammation may contribute to
depression. Yet, the link between peripheral inflammation and neuroinflammation in …

Introduction: In recent years, purinergic signaling via the P2X7 receptor (P2X7R) on
microglia has repeatedly been implicated in depression genesis. However, it remains …