Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …
associated with systemic inflammation. Recent studies have reported stress-induced …
[HTML][HTML] Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology
Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …
shown that exogenous administration of cytokines or inflammatory stimuli that induce …
Inflammation, stress and depression: an exploration of ketamine's therapeutic profile
Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
[HTML][HTML] Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine …
Increased inflammation in major depressive disorder (MDD) has been associated with low
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …
Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort
Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …
Neuroimmune mechanisms of opioid use disorder and recovery: Translatability to human studies, and future research directions
ER Butelman, RZ Goldstein, CA Nwaneshiudu… - Neuroscience, 2023 - Elsevier
Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …
Is depression the missing link between inflammatory mediators and cancer?
B Polityńska, O Pokorska, AM Wojtukiewicz… - Pharmacology & …, 2022 - Elsevier
Patients with cancer are at greater risk of developing depression in comparison to the
general population and this is associated with serious adverse effects, such as poorer …
general population and this is associated with serious adverse effects, such as poorer …
Treatment-resistant depression with anhedonia: Integrating clinical and preclinical approaches to investigate distinct phenotypes
CA Kelly, KB Freeman, JA Schumacher - Neuroscience & Biobehavioral …, 2022 - Elsevier
In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have
emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated …
emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated …
[HTML][HTML] Neuroinflammation in the amygdala is associated with recent depressive symptoms
W Zhang, J Rutlin, SA Eisenstein, Y Wang… - Biological Psychiatry …, 2023 - Elsevier
Background Converging evidence suggests that elevated inflammation may contribute to
depression. Yet, the link between peripheral inflammation and neuroinflammation in …
depression. Yet, the link between peripheral inflammation and neuroinflammation in …
[HTML][HTML] The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation
IA von Mücke-Heim, J Martin, M Uhr, C Ries… - Frontiers in …, 2023 - frontiersin.org
Introduction: In recent years, purinergic signaling via the P2X7 receptor (P2X7R) on
microglia has repeatedly been implicated in depression genesis. However, it remains …
microglia has repeatedly been implicated in depression genesis. However, it remains …