Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the …

Purpose: To examine studies of normal colon and colorectal cancer for evidence that the
location of the primary tumor proximal or distal to the splenic flexure of the colon may …

DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for
mutations in three genes@ Pi, SRP79, and DP2. 5) located within a 166 kb region deleted in …

We developed mobility shift analysis of single-stranded DNAs on neutral polyacrylamide gel
electrophoresis to detect DNA polymorphisms. This method follows digestion of genomic …

Recent studies suggest that one or more genes on chromosome 5q21 are important for the
development of colorectal cancers, particularly those associated with familial adenomatous …

Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17
occur in over 75% of colorectal carcinomas. Twenty chromosome 17p markers were used to …

Previous studies suggested that one or more genes on chromosome 5q21 are responsible
for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS) …

Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis
(FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop …

A substraction cDNA library enriched for RNA sequences preferentially expressed in growth-
arrested cells was prepared. Six cDNA clones were identified, varying in abundance from …

Abstract 102 patients with familial adenomatous polyposis underwent upper gastrointestinal
endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal …