Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions

J Puschhof, C Pleguezuelos-Manzano, H Clevers - Cell host & microbe, 2021 - cell.com
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

TLR2 and TLR4 in Parkinson's disease pathogenesis: The environment takes a toll on the gut

AM Gorecki, CC Anyaegbu, RS Anderton - Translational …, 2021 - Springer
Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

The composition of the perinatal intestinal microbiota in cattle

MJ Alipour, J Jalanka, T Pessa-Morikawa… - Scientific reports, 2018 - nature.com
Recent research suggests that the microbial colonization of the mammalian intestine may
begin before birth, but the observations are controversial due to challenges in the reliable …

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

M Zimmermann, KR Patil, A Typas… - Molecular systems …, 2021 - embopress.org
Broad‐spectrum antibiotics target multiple gram‐positive and gram‐negative bacteria, and
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …

Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors

SC Pearce, HG Coia, JP Karl… - Frontiers in …, 2018 - frontiersin.org
The gut microbiome is extremely important for maintaining homeostasis with host intestinal
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …

[HTML][HTML] Host/microbiota interactions in health and diseases—Time for mucosal microbiology!

N Daniel, E Lécuyer, B Chassaing - Mucosal Immunology, 2021 - Elsevier
During the last 20 years, a new field of research delineating the importance of the microbiota
in health and diseases has emerged. Inappropriate host-microbiota interactions have been …

[HTML][HTML] Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation

CJG Pinto, MÁ Ávila-Gálvez, Y Lian, P Moura-Alves… - Redox Biology, 2023 - Elsevier
Abstract The Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor
able to control complex transcriptional processes in several cell types, which has been …

Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age

J Barrila, A Crabbé, J Yang, K Franco… - Infection and …, 2018 - Am Soc Microbiol
Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …

Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway

C Martin-Gallausiaux, D Garcia-Weber… - Gut …, 2022 - Taylor & Francis
The commensal bacteria that make up the gut microbiota impact the health of their host on
multiple levels. In particular, the interactions taking place between the microbe-associated …