Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …

Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70
years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ …

Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …

The first evidence of individual targeting medicine appeared in ancient times thousands of
years ago. Various therapeutic approaches have been established since then. However …

CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133
Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White …

Individual and population differences in polymorphic cytochrome P 450 enzyme function
have been known for decades. The biological significance of these differences has now …

Debrisoquine is a probe drug for in vivo phenotyping of human CYP2D6 metabolic activity.
However, debrisoquine is positively charged under physiological conditions and it is unclear …

Venlafaxine (VEN) is one of the safest and most effective drugs used in the treatment of
selective serotonin reuptake inhibitors-resistant depression, and thereby it is nowadays one …

Applications of omics technologies in the postgenomics era swiftly expanded from rare
monogenic disorders to multifactorial common complex diseases, pharmacogenomics, and …