The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

The Rad50 interacting protein 1 (Rint1) is a key player in vesicular trafficking between the
ER and Golgi apparatus. Biallelic variants in RINT1 cause infantile-onset episodic acute …

Based on studies with a fluorescent reporter dye, Mito Thermo Yellow (MTY), and the
genetically encoded gTEMP ratiometric fluorescent temperature indicator targeted to …

Glycolysis is the fundamental cellular process that permits cancer cells to convert energy
and grow anaerobically. Recent developments in molecular biology have made it evident …

Cognizance of the nano–bio interaction further bolsters cancer nanomedicine. Accentuating
it, we have unveiled the potential therapeutic role of a cobalt nanoparticle (Co NP), the …

Metabolic heterogeneity of tumor microenvironment (TME) is a hallmark of cancer and a big
barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative …

Objective Allopregnanolone (Allo) is a neurosteroid with pleiotropic action in the brain that
includes neurogenesis, oligogenesis, human and rodent neural stem cell regeneration …

Mitochondrial networks remodel their connectivity, content, and subcellular localization to
support optimized energy production in conditions of increased environmental or cellular …

mTORC1 integrates environmental signals to promote anabolism and repress catabolism. In
this issue of Nature Metabolism, Hosios et al. identify a role for mTORC1 in controlling …

Once considered passive cells of the central nervous system (CNS), glia are now known to
actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in …