Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The birth of an intersex child prompts a long-term management strategy that involves a
myriad of professionals working with the family. There has been progress in diagnosis …

THE BIRTH of an intersex child prompts a long-term management strategy that involves
myriad professionals working with the family. There has been progress in diagnosis, surgical …

The germ-cell tumours are a fascinating group of neoplasms because of their unusual
biology and the spectacular therapeutic results that have been obtained in these tumours …

Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …

The risk for the development of germ cell tumors is an important factor to deal with in the
management of patients with disorders of sex development (DSD). However, this risk is often …

Testicular biopsy is a crucial assessment in reproductive practice with diagnostic and
prognostic importance for assisted reproductive technologies (ARTs) and risk of testicular …

Background: Whereas testicular cancer incidence rates have been widely reported in
populations of Northern European ancestry, rates in other populations have been less …

Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …