Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …

The p53 protein plays a critical role in the prevention of genome mutations in the body,
however, this protein is frequently mutated in cancer and almost all cancers exhibit …

The tumor suppressor protein p53 is inactivated in the majority of human cancers and
remains a prime target for developing new drugs to reactivate its tumor suppressing activity …

Aging is characterized by the accumulation of proteins that display amyloid-like behavior.
However, the molecular mechanisms by which these proteins arise remain unclear. Here …

One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53,
which is mutated with high frequency in more cancers than any other tumor suppressor …

Abstract p53 is an important tumor suppressor, and the complexities of p53 function in
regulating cancer cell behaviour are well established. Many cancers lose or express mutant …

Biological liquid–liquid phase separation has gained considerable attention in recent years
as a driving force for the assembly of subcellular compartments termed membraneless …

Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco
products, including smokeless tobacco (ST), generally contain tobacco-specific N …

In recent years, an increasing number of long non‑coding RNAs (lncRNAs) have been
discovered using microarrays and nucleic acid sequencing technology. LncRNAs exert …

The p53 protein is a pleiotropic regulator working as a tumor suppressor and as an
oncogene. Depending on the cellular insult and the mutational status, p53 may trigger …