The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …

Chromogranin A (CgA) is a member of the granins, a family of acidic proteins found in
abundance in (neuro) endocrine cells (eg, in chromaffin cells) and in some tumors. Like …

High-throughput proteomics is made possible by a combination of modern mass
spectrometry instruments capable of generating many millions of tandem mass (MS2) …

A significant portion of mammalian proteomes is secreted to the extracellular space to fulfill
crucial roles in cell-to-cell communication. To best recapitulate the intricate and multi-faceted …

Neuropeptides are essential for cell–cell communication in neurological and endocrine
physiological processes in health and disease. While many neuropeptides have been …

Neuropeptides are short peptides in the range of 3–40 residues that are secreted for cell-cell
communication in neuroendocrine systems. In the nervous system, neuropeptides comprise …

Three forms of serpinin peptides, serpinin (Ala26Leu), pyroglutaminated (pGlu)-serpinin
(pGlu23Leu), and serpinin-Arg-Arg-Gly (Ala29Gly), are derived from cleavage at pairs of …

The social amoebae (Dictyostelia) use quorum sensing-like communication systems to
coordinate the periodic transition from uni-to multicellularity. The monophyletic descent of …

Neuropeptide identification in mass spectrometry experiments using database search
programs developed for proteins is challenging. Unlike proteins, the detection of the …

Neuropeptides are vital for cell-cell communication and function in the regulation of the
nervous and endocrine systems. They are generated by post-translational modification …