Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

Integrated multi-omics evaluation of 823 tumors from advanced renal cell carcinoma (RCC)
patients identifies molecular subsets associated with differential clinical outcomes to …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

As one of the two highly conserved cellular degradation systems, autophagy plays a critical
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …

The accumulation of senescent cells is recognised as a driver of tissue and organismal
ageing. One of the gold‐standard hallmarks of a senescent cell is an increase in lysosomal …

Response and adaptation to stress are critical for the survival of all living organisms. The
regulation of the transcriptional machinery is an important aspect of these complex …

Old age is associated with a greater burden of disease, including neurodegenerative
disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic …