Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal
characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas …

Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the
patients with colorectal cancer (CRC). In this study, we identified the chemoresistance …

Somatic copy number variations (CNV) may drive cancer progression through both coding
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …

Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Selective autophagy represents the major quality control mechanism that ensures proper
turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER) …

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …