Acid fasting: modulation of Mycobacterium tuberculosis metabolism at acidic pH
JJ Baker, SJ Dechow, RB Abramovitch - Trends in microbiology, 2019 - cell.com
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …
Pharmacological and molecular mechanisms behind the sterilizing activity of pyrazinamide
Inclusion of pyrazinamide (PZA) in the tuberculosis (TB) drug regimen during the 1970s
enabled a reduction in treatment duration from 12 to 6 months. PZA has this remarkable …
enabled a reduction in treatment duration from 12 to 6 months. PZA has this remarkable …
The bewildering antitubercular action of pyrazinamide
Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action
remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid …
remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid …
Pyrazinoic acid inhibits mycobacterial coenzyme A biosynthesis by binding to aspartate decarboxylase PanD
P Gopal, W Nartey, P Ragunathan… - ACS infectious …, 2017 - ACS Publications
Previously, we showed that a major in vitro and in vivo mechanism of resistance to
pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug …
pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug …
Comparative proteomic investigation unravels the pathobiology of Mycobacterium fortuitum biofilm
Biofilm formation by Mycobacterium fortuitum causes serious threats to human health due to
its increased contribution to nosocomial infections. In this study, the first comprehensive …
its increased contribution to nosocomial infections. In this study, the first comprehensive …
Mycobacterium tuberculosis requires the outer membrane lipid phthiocerol dimycocerosate for starvation-induced antibiotic tolerance
AM Block, SB Namugenyi, NP Palani, AM Brokaw… - Msystems, 2023 - Am Soc Microbiol
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of
tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis …
tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis …
Pyrazinamide susceptibility is driven by activation of the SigE-dependent cell envelope stress response in mycobacterium tuberculosis
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other
antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The …
antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The …
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase …
Through mutant selection on agar containing pyrazinoic acid (POA), the bioactive form of the
prodrug pyrazinamide (PZA), we recently showed that missense mutations in the aspartate …
prodrug pyrazinamide (PZA), we recently showed that missense mutations in the aspartate …
Recombinant expression and functional characterization of FadD2 protein in Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is a crucial and highly destructive intracellular pathogen
responsible for causing tuberculosis (TB). The emergence and dissemination of multi-drug …
responsible for causing tuberculosis (TB). The emergence and dissemination of multi-drug …