[HTML][HTML] Advances and trends in omics technology development
X Dai, L Shen - Frontiers in Medicine, 2022 - frontiersin.org
The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …
miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification in
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
eukaryotic mRNA. It is dynamically installed and removed, and acts as a new layer of mRNA …
Transcriptome-wide mapping of internal N7-methylguanosine methylome in mammalian mRNA
Summary N 7-methylguanosine (m 7 G) is a positively charged, essential modification at the
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
Action mechanisms and research methods of tRNA-derived small RNAs
Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
Abstract N 6-Methyladenosine (m6A) RNA modification is present in messenger RNAs
(mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although …
(mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although …
HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification of
messenger RNA. While the presence of m 6 A on transcripts can impact nuclear RNA fates …
messenger RNA. While the presence of m 6 A on transcripts can impact nuclear RNA fates …
Regulation by 3′-untranslated regions
C Mayr - Annual review of genetics, 2017 - annualreviews.org
3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
RNA‐Seq methods for transcriptome analysis
R Hrdlickova, M Toloue, B Tian - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Deep sequencing has been revolutionizing biology and medicine in recent years, providing
single base‐level precision for our understanding of nucleic acid sequences in high …
single base‐level precision for our understanding of nucleic acid sequences in high …
Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
RML Queiroz, T Smith, E Villanueva… - Nature …, 2019 - nature.com
Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on
capture of polyadenylated RNAs and cannot recover proteins that interact with …
capture of polyadenylated RNAs and cannot recover proteins that interact with …