RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …

There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC).
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …

How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …

The three mammalian RAS genes (HRAS, NRAS and KRAS) encode four proteins that play
central roles in cancer biology. Among them, KRAS is mutated more frequently in human …

Ras proteins require membrane association for proper function. This process is tightly
regulated by reversible palmitoylation that controls not only the distribution over different …

K-Ras4B preferentially activates Raf-1. The high-affinity interaction of Ras-binding domain
(RBD) of Raf with Ras was solved, but the relative position of Raf's cysteine-rich domain …

Calmodulin (CaM) uniquely promotes signaling by oncogenic K-Ras, but not by N-Ras or H-
Ras. How CaM interacts with K-Ras and how this stimulates cell proliferation are among the …

Deregulation of KRAS4b signaling pathway has been implicated in 30% of all cancers.
Membrane localization of KRAS4b is an essential step for the initiation of the downstream …