Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Infection by protozoan parasites of the genus Leishmania results in the development of
leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people …

Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …

The leishmaniases are vector-borne diseases that have a broad global distribution
throughout much of the Americas, Africa, and Asia. Despite representing a significant public …

Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in
several conditions. However, we have little understanding of the mechanisms by which …

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the
parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells …

Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury,
inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated …

Patients infected with Leishmania braziliensis develop chronic lesions that often fail to
respond to treatment with antiparasite drugs. To determine whether genes whose …

As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …