Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most
common genetic alteration identified to date in thyroid papillary carcinomas. The prevalence …

The activation of the RET proto-oncogene contributes to the development of human cancers
in two different ways. Somatic rearrangements of RET with a variety of activating genes …

Thyroid carcinoma is the most frequent endocrine cancer accounting for 5–10% of thyroid
nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all …

Objective Treatment options for patients with radioactive iodine (RaI) refractory metastases
of differentiated thyroid carcinoma (DTC) are limited. We studied the effects of the multitarget …

The RET proto-oncogene encodes a cell membrane tyrosine-kinase receptor protein whose
ligands belong to the glial cell line–derived neurotrophic factor. RET functions as a …

Context: RET/PTC rearrangements have been reported in papillary thyroid carcinomas with
variable frequency in studies that used different detection methods. Objective: Our objective …

Abstract microRNAs (miRNAs) are approximately 22 nt RNAs that negatively regulate target
gene expression. Their dysregulation has been implicated in the pathogenesis of a number …

Cytological examination of fine needle aspiration biopsy is the primary means for
distinguishing benign from malignant nodules. However, as inconclusive cytology is very …

Noninvasive thyroid nodules that exhibit borderline morphological signs of papillary cancer
are difficult to diagnose and we do not know if they represent papillary carcinoma precursor …

The nuclear disaster that occurred in Chernobyl in 1986 offered the unique opportunity to
study the molecular genetics of one human tumor type, papillary carcinoma of the thyroid …