Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity
X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …
notably for therapeutic agent development. Genome sequencing revealed that the number …
A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a
type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA …
type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA …
From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites
T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …
the fungus to its environment. Although some of these natural products are promising …
Genetic platforms for heterologous expression of microbial natural products
Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
Engineered biosynthesis of natural products in heterologous hosts
Natural products produced by microorganisms and plants are a major resource of
antibacterial and anticancer drugs as well as industrially useful compounds. However, the …
antibacterial and anticancer drugs as well as industrially useful compounds. However, the …
Recent advances in natural product discovery
Highlights•Natural products are discovered through top-down and bottom-up
approaches.•Diverse sampling provides diverse natural products.•Powerful analytical …
approaches.•Diverse sampling provides diverse natural products.•Powerful analytical …
Strategies for mining fungal natural products
Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …
hand their potential to provide beneficial antibiotics and immunosuppressants has been …
[HTML][HTML] Natural products chemistry: The emerging trends and prospective goals
RA Khan - Saudi pharmaceutical journal, 2018 - Elsevier
The role and contributions of natural products chemistry in advancements of the physical
and biological sciences, its interdisciplinary domains, and emerging of new avenues by …
and biological sciences, its interdisciplinary domains, and emerging of new avenues by …
RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression
H Wang, Z Li, R Jia, Y Hou, J Yin, X Bian, A Li… - Nature protocols, 2016 - nature.com
Abstract Full-length RecE and RecT from Rac prophage mediate highly efficient linear–
linear homologous recombination that can be used to clone large DNA regions directly from …
linear homologous recombination that can be used to clone large DNA regions directly from …