Cl− is the major extracellular (Cl− out) and intracellular (Cl− in) anion whose concentration
is actively regulated by multiple transporters. These transporters generate Cl− gradients …

Collagen IV scaffold is a primordial innovation enabling the assembly of a fundamental
architectural unit of epithelial tissues—a basement membrane attached to polarized cells. A …

Collagen IV is an essential structural protein in all metazoans. It provides a scaffold for the
assembly of basement membranes, a specialized form of extracellular matrix, which anchors …

Collagens are the most abundant proteins in the body and among the most biosynthetically
complex. A molecular ensemble of over 20 endoplasmic reticulum resident proteins …

We identified a genetic variant, an 8-residue appendage, of the α345 hexamer of collagen IV
present in patients with glomerular basement membrane diseases, Goodpasture's disease …

Collagen molecules are crucial extracellular players in animal tissue development and in
functions ranging from ultrafiltration to organism locomotion. Among the 28 types of collagen …

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold
that is present in patients with glomerular basement membrane diseases, Goodpasture's …

Extracellular matrix mechanics influence diverse cellular functions, yet surprisingly little is
known about the mechanical properties of their constituent collagen proteins. In particular …

The assembly of basement membranes (BMs) into tissue-specific morphoregulatory
structures requires non-core BM components. Work in Drosophila indicates a principal role …

There is a growing confidence that these approaches will ultimately provide cure for Alport
patients. The development of therapy will be accelerated by studies that provide a deeper …