The unique and complex structure of papain-like protease (PL pro) of the SARS-CoV-2 virus
represents a difficult challenge for antiviral development, yet it offers a compelling validated …

The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CLpro), and papain-like
protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as …

The SARS-CoV-2 papain-like protease (PLpro), essential for viral processing and immune
response disruption, is a promising target for treating acute infection of SARS-CoV-2. To …

Several viruses are now known to code for deubiquitinating proteases in their genomes.
Ubiquitination is an essential post-translational modification of cellular substrates involved in …

Natural antioxidants have become the subject of many investigations due to the role that
they play in the reduction of oxidative stress. Their main scavenging mechanisms concern …

A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications
in cells, allowing the evasion of antiviral immune response mechanisms. In this study …

The COVID-19 pandemic is caused by SARS-CoV-2, a highly transmissible and pathogenic
RNA betacoronavirus. Like other RNA viruses, SARS-CoV-2 continues to evolve with or …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), has not yet been eradicated. SARS-CoV-2 has two types of …

Although the COVID-19 pandemic caused by SARS-CoV-2 viruses is officially over, the
search for new effective agents with activity against a wide range of coronaviruses is still an …

Although COVID-19 is not a pandemic anymore, the virus frequently mutates, resulting in
new strains and presenting global public health challenges. The lack of oral antiviral drugs …