There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

B cells can present antigens to CD4+ T cells, but it is thought that dendritic cells (DCs) are
the primary initiators of naive CD4+ T cell responses. Nanoparticles, including virus-like …

Gender bias and the role of sex hormones in autoimmune diseases are well established. In
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …

There is increasing evidence supporting a role for B cells in tumor immunology.
Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential …

Type 1 diabetes is an autoimmune disorder afflicting millions of people worldwide. Once
diagnosed, patients require lifelong insulin treatment and can experience numerous disease …

Purpose: Tumor-infiltrating lymphocytes (TIL), in particular CD8+ T cells and CD20+ B cells,
are strongly associated with survival in ovarian cancer and other carcinomas. Although …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Gut microbiota profoundly affect gut and systemic diseases, but the mechanism whereby
microbiota affect systemic diseases is unclear. It is not known whether specific microbiota …

Programmed death 1 (PD-1), an inhibitory receptor expressed on activated lymphocytes,
regulates tolerance and autoimmunity. PD-1 has two ligands: PD-1 ligand 1 (PD-L1), which …