Asymmetric metal based catalysis has advanced quickly in recent years, with its efficiency
relying exclusively on chiral ligands. Rational design and meticulous selection of chiral …

Grignard addition is one of the most important methods used for syntheses of alcohol
compounds and has been known for over a hundred years. However, research on …

Direct asymmetric functionalization of the pyridyl C–H bond represents a longstanding
challenge in organic chemistry. We herein describe the first enantioselective para-C–H …

Compounds bearing oxa-quaternary carbon centers, such as chiral tertiary alcohols, ethers,
esters, and acetals, are widely found in a number of bioactive compounds, natural products …

The reaction of common acyl-metal species (acyl anion) with aldehydes to furnish acyloins
has received much less attention and specifically was restricted to using preformed …

Despite the importance of enantioenriched alcohols in medicinal chemistry, total synthesis,
and materials science, the efficient and selective construction of enantioenriched tertiary …

Enantioenriched alcohols comprise much of the framework of organic molecules. Here, we
first report that chiral nickel complexes can catalyze the intermolecular enantioselective …

Performing asymmetric cross‐coupling reactions between propargylic electrophiles and aryl
nucleophiles is a well‐established method to build enantioenriched benzylic alkynes. Here …

The direct upgrading reaction of simple and readily available achiral alcohols via C–H
functionalization is an ideal strategy to prepare value-added chiral higher alcohols. Herein …

Acyclic quaternary carbon stereocenters exist widely in natural products and bioactive
molecules, but their enantioselective construction remains a prominent challenge. In …