Muscular exercise requires transitions to and from metabolic rates often exceeding an order
of magnitude above resting and places prodigious demands on the oxidative machinery and …

This review provides a pulmonary-focused description of the age-associated changes in the
integrative physiology of exercise, including how declining lung function plays a role in …

The activities of daily living typically occur at metabolic rates below the maximum rate of
aerobic energy production. Such activity is characteristic of the nonsteady state, where …

Sprint interval training (SIT) and traditional endurance training elicit similar physiological
adaptations. From the perspective of metabolic function, superior glucose regulation is a …

Despite its crucial importance, scientists interested in the limitations of human physical
performance have only just started to give the field of oxygen uptake kinetics the attention it …

Key Points The relationship between age and physiological function remains poorly defined
and there are no physiological markers that can be used to reliably predict the age of an …

The time course and mechanisms of adjustment of pulmonary oxygen uptake (V̇o2)
kinetics (time constant τV̇o2p) were examined during step transitions from 20 W to …

Evolutionary forces drive beneficial adaptations in response to a complex array of
environmental conditions. In contrast, over several millennia, humans have been so …

Pulmonary O2 uptake (V̇o2p) and muscle deoxygenation kinetics were examined during
moderate-intensity cycling (80% lactate threshold) without warm-up and after heavy-intensity …

Phase 2 pulmonary O2 uptake (V̇o2p) kinetics are slowed with aging. To examine the
effect of aging on the adaptation of V̇o2p and deoxygenation of the vastus lateralis muscle …