TP53 encodes a transcription factor that is centrally-involved in several pathways, including
the control of metabolism, the stress response, DNA repair, cell cycle arrest, senescence …

Summary p53 was discovered 45 years ago as an SV40 large T antigen binding protein,
coded by the most frequently mutated TP53 gene in human cancers. As a transcription …

Tumor genomes often harbor a complex spectrum of single nucleotide alterations and
chromosomal rearrangements that can perturb protein function. Prime editing has been …

Cancer-relevant mutations in the oligomerization domain (OD) of the p53 tumor suppressor
protein, unlike those in the DNA binding domain, have not been well elucidated. Here, we …

Missense mutations in the DNA binding domain of p53 are characterized as structural or
contact mutations based on their effect on the conformation of the protein. These mutations …

Tumour suppressor p53 plays a key role in the development of cancer and has therefore
been widely studied in recent decades. While it is well known that p53 is biologically active …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignant disease with a dismal
prognosis. In the past decades, a plethora of genetically engineered mouse models …

In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups
describe functional analyses of a common dimeric mutant of p53 found in Li–Fraumeni …

The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around
half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations …

TP53 is the most frequently mutated gene in human cancer. While it is well understood that
the ability of p53 to act as a transcription factor is required for tumor suppression, the key …