Chemical modifications of histones and DNA, such as histone methylation, histone
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …

DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

In experimental animals, maternal diet during the periconceptional period influences the
establishment of DNA methylation at metastable epialleles in the offspring, with permanent …

The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …

The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

Prenatal famine in humans has been associated with various later-life consequences,
depending on the gestational timing of the insult and the sex of the exposed individual …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its
derivatives serve as components of structural lipoproteins, blood and membrane lipids, and …