Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells
exhibit distinct metabolic phenotypes to fuel their proliferation and progression. The …

Despite the high prevalence of both cervico-vaginal human papillomavirus (HPV) infection
and bacterial vaginosis (BV) worldwide, their causal relationship remains unclear. While BV …

The occurrence and development of tumors depend on the tumor microenvironment (TME),
which consists of various types of cellular and acellular components. Tumor-associated …

Myoferlin, an emerging oncoprotein, has been associated with a low survival in several
cancer types including pancreas ductal adenocarcinoma where it controls mitochondria …

Breast cancer represents a highly heterogeneous disease comprised by several subtypes
with distinct histological features, underlying molecular etiology and clinical behaviors. It is …

Tumor cells, including cancer stem cells (CSCs) resistant to radio-and chemotherapy, must
enhance metabolism to meet the extra energy demands to repair and survive such …

Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion
with incoming organelles and degradation of substrates within their lumen. Pancreatic …

Triple-negative breast cancers (TNBCs) lack progesterone and estrogen receptors and do
not have amplified human epidermal growth factor receptor 2, the main therapeutic targets …

Cancer research is increasingly dependent of patient-derived xenograft model (PDX).
However, a major point of concern regarding the PDX model remains the replacement of the …