Selective functionalization of unactivated C–H bonds, water oxidation, and dioxygen
reduction are extremely important reactions in the context of finding energy carriers and …

The rational design of well-defined, first-row transition metal complexes that can activate
dioxygen has been a challenging goal for the synthetic inorganic chemist. The activation of …

Abstract Significance: Hydrogen sulfide (H2S), produced by the desulfuration of cysteine or
homocysteine, functions as a signaling molecule in an array of physiological processes …

Synthesis of cysteine as a product of the transsulfuration pathway can be viewed as part of
methionine or homocysteine degradation, with cysteine being the vehicle for sulfur …

Abstract Cysteine dioxygenase 1 (Cdo1) is a key enzyme in taurine synthesis. Here we
show that Cdo1 promotes lipolysis in adipose tissue. Adipose-specific knockout of Cdo1 in …

The activation of dioxygen (O 2) by metalloenzymes proceeds by binding O 2 at their active
sites and then generating highly reactive, thermally unstable metal-oxygen intermediates …

Nature has developed large groups of enzymatic catalysts with the aim to transfer substrates
into useful products, which enables biosystems to perform all their natural functions. As …

Cysteine dioxygenase (CDO) is a vital enzyme for human health involved in the
biodegradation of toxic cysteine and thereby regulation of the cysteine concentration in the …

The enzyme isopenicillin N synthase (IPNS) installs the β-lactam and thiazolidine rings of
the penicillin core into the linear tripeptide l-δ-aminoadipoyl-l-Cys-d-Val (ACV) on the …

Hydrogen sulfide (H 2 S) is a recently described endogenously produced gaseous signaling
molecule that influences various cellular processes in the central nervous system …