According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour
progression not only by providing cancer cells with increased proliferative potential and an …

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …

The Krebs cycle byproduct itaconate has recently emerged as an important metabolite
regulating macrophage immune functions, but its role in tumor cells remains unknown. Here …

The preferable antigen delivery profile accompanied by sufficient adjuvants favors vaccine
efficiency. Mitochondria, which feature prokaryotic characteristics and contain various …

Purpose: Transcriptomic subtyping holds promise for personalized therapy in extensive-
stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral …

In Alzheimer's disease (AD), dysfunctional mitochondrial metabolism is associated with
synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for …

The way that cancer cells die inspires treatment regimens and cytolytic cuproptosis induced
by copper complexes, like copper (II) bis (diethyldithiocarbamate)(CuET), has emerged as a …

Mitochondrial regulation plays a crucial role in cancer immunity in the tumor
microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells …

The occurrence and development of tumors require the metabolic reprogramming of cancer
cells, namely the alteration of flux in an autonomous manner via various metabolic pathways …