CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

The insertion of proteins into the prokaryotic plasma membrane is catalyzed by translocases
and insertases. On one hand, the Sec translocase operates as a transmembrane channel …

Lactobacillus is a diverse genus that includes species of industrial and biomedical interest.
Lactiplantibacillus pentosus, formerly known as Lactobacillus pentosus, is a recently …

Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ)
treatment is widely used for induction of persisters in bacteria. Although FQs that target DNA …

In this paper, time independent Schrodinger equation (TISE) for rotating Morse potential is
solved numerically using matrix mechanics approach with Fourier sine basis, to obtain the ro …

The fundamental to the pathogenicity of Mycobacterium tuberculosis (Mtb) is the modulation
in the control mechanisms that play a role in sensing and counteracting the microbicidal …

Mycobacteria, including the infamous pathogen Mycobacterium tuberculosis, are high-GC
Gram-positive bacteria with a distinctive cell envelope. Although there is a typical inner …

Heterogeneity in the distribution of nutrients and oxygen gradients during biofilm growth
gives rise to changes in phenotype. There has been long term interest in identifying spatial …

Due to lipid-rich cell wall, slow growth and pathogenic nature, it is difficult to manipulate
Mycobacterium tuberculosis (Mtb) genome by conventional tools. Recently we have …

Background Tuberculosis currently stands as the second leading cause of deaths worldwide
due to single infectious agent after Severe Acute Respiratory Syndrome Coronavirus 2 …