Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Chemotherapy, one of the principal approaches for cancer patients, plays a crucial role in
controlling tumor progression. Clinically, tumors reveal a satisfactory response following the …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …

Aneuploidy is one of the most obvious differences between normal and cancer cells.
However, there remains debate over how aneuploid cells arise and whether or not they are …

The turn of the 21st century had witnessed a surge of interest in the centrosome and its
causal relation to human cancer development-a postulate that has existed for almost a …

Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell
Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

Polyploidy, an increased number of chromosome sets, is a surprisingly common
phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in …