Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
Y Su, B Zhao, L Zhou, Z Zhang, Y Shen, H Lv… - Cancer letters, 2020 - Elsevier
Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …
intracellular microenvironment, which is under the constitutive control of glutathione …
Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities
R Miao, X Fang, Y Zhang, J Wei, Y Zhang… - Cell Death & Disease, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …
body of evidence suggests that iron imbalance is a key factor in the development of several …
RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer
X Sui, R Zhang, S Liu, T Duan, L Zhai… - Frontiers in …, 2018 - frontiersin.org
Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-
dependent accumulation of reactive oxygen species (ROS) within the cell. It has been …
dependent accumulation of reactive oxygen species (ROS) within the cell. It has been …
[HTML][HTML] Iron homeostasis and oxidative stress: An intimate relationship
Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …
component of various metalloproteins it is involved in critical biochemical processes such as …
Dental enamel formation and implications for oral health and disease
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …
species and provides maximum durability that allows teeth to function as weapons and/or …
Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis
Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for
cancer treatment. BAY 11–7085 (BAY), which is a well-known IκBα inhibitor, suppressed …
cancer treatment. BAY 11–7085 (BAY), which is a well-known IκBα inhibitor, suppressed …
Iron metabolism in obesity and metabolic syndrome
Á González-Domínguez, FM Visiedo-García… - International journal of …, 2020 - mdpi.com
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on
health. Particularly, childhood obesity has become one of the main public health problems in …
health. Particularly, childhood obesity has become one of the main public health problems in …
Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
Ferroptosis is an iron-dependent, oxidative cell death, and is distinct from apoptosis,
necrosis and autophagy. In this study, we demonstrated that lysosome disrupting agent …
necrosis and autophagy. In this study, we demonstrated that lysosome disrupting agent …
Iron overload, oxidative stress, and ferroptosis in the failing heart and liver
D Mancardi, M Mezzanotte, E Arrigo, A Barinotti… - Antioxidants, 2021 - mdpi.com
Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …
impairment of redox homeostasis and cellular death. Iron overload is often associated with …
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation
The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …
research across different fields including materials science, nanotechnology, biotechnology …