[HTML][HTML] Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease

I Beltran-Hortelano, V Alcolea, M Font… - Bioorganic & medicinal …, 2022 - Elsevier
Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Therapeutic efficacy of benzimidazole and its analogs: An update

NJ Basha - Polycyclic Aromatic Compounds, 2023 - Taylor & Francis
Benzimidazoles, one of the nitrogen heterocycles, possess pharmaceutical and biological
potential. This heterocycle has been known for pharmacological activities such as …

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …

Cytotoxic activity of quinolinequinones in cancer: In vitro studies, molecular docking, and ADME/PK profiling

AT Jannuzzi, AM Yilmaz Goler, D Shilkar… - Chemical Biology & …, 2023 - Wiley Online Library
Abstract Lead molecules containing 1, 4‐quinone moiety are intriguing novel compounds
that can be utilized to treat cancer owing to their antiproliferative activities. Nine previously …

A comprehensive review on potential candidates for the treatment of chagas disease

S Pathak, M Bhardwaj, N Agrawal… - Chemical Biology & …, 2023 - Wiley Online Library
Twenty different infectious disorders induced by bacteria, viruses, and parasites are
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …

Terminal phenoxy group as a privileged moiety of the drug scaffold—A short review of most recent studies 2013–2022

P Kozyra, M Pitucha - International Journal of Molecular Sciences, 2022 - mdpi.com
The terminal phenoxy group is a moiety of many drugs in use today. Numerous literature
reports indicated its crucial importance for biological activity; thus, it is a privileged scaffold in …

Predicting target–ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery

P Ruiz Puentes, L Rueda-Gensini, N Valderrama… - Scientific reports, 2022 - nature.com
Drug Discovery is an active research area that demands great investments and generates
low returns due to its inherent complexity and great costs. To identify potential therapeutic …

Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver (I) complexes

E Arı, N Şahin, E Üstün, M Dündar, H Karcı… - JBIC Journal of …, 2023 - Springer
In this study, a series of N-functionalized benzimidazole silver (I) complexes were prepared
and characterized by FT-IR, 1H, 13C {1H} NMR spectroscopy, and elemental analysis …

Nitrogen Enriched Tröger's Base Polymers of Intrinsic Microporosity for Heterogeneous Catalysis

N Hawkins, AR Antonangelo, M Wood… - ACS Applied Polymer …, 2024 - ACS Publications
Heterogeneous catalysis is significantly enhanced by the use of highly porous polymers with
specific functionalities, such as basic groups, which accelerate reaction rates. Polymers of …

Highly Active Small Aminated Quinolinequinones against Drug-Resistant Staphylococcus aureus and Candida albicans

H Yıldırım, N Bayrak, M Yıldız, FN Yılmaz… - Molecules, 2022 - mdpi.com
Two subseries of aminated quinolinequinones (AQQs, AQQ1–16) containing electron-
withdrawing group (EWG) or electron-donating group (EDG) in aryl amine moiety were …