[HTML][HTML] Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease
I Beltran-Hortelano, V Alcolea, M Font… - Bioorganic & medicinal …, 2022 - Elsevier
Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
Therapeutic efficacy of benzimidazole and its analogs: An update
NJ Basha - Polycyclic Aromatic Compounds, 2023 - Taylor & Francis
Benzimidazoles, one of the nitrogen heterocycles, possess pharmaceutical and biological
potential. This heterocycle has been known for pharmacological activities such as …
potential. This heterocycle has been known for pharmacological activities such as …
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose
L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …
Cytotoxic activity of quinolinequinones in cancer: In vitro studies, molecular docking, and ADME/PK profiling
AT Jannuzzi, AM Yilmaz Goler, D Shilkar… - Chemical Biology & …, 2023 - Wiley Online Library
Abstract Lead molecules containing 1, 4‐quinone moiety are intriguing novel compounds
that can be utilized to treat cancer owing to their antiproliferative activities. Nine previously …
that can be utilized to treat cancer owing to their antiproliferative activities. Nine previously …
A comprehensive review on potential candidates for the treatment of chagas disease
Twenty different infectious disorders induced by bacteria, viruses, and parasites are
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …
Terminal phenoxy group as a privileged moiety of the drug scaffold—A short review of most recent studies 2013–2022
P Kozyra, M Pitucha - International Journal of Molecular Sciences, 2022 - mdpi.com
The terminal phenoxy group is a moiety of many drugs in use today. Numerous literature
reports indicated its crucial importance for biological activity; thus, it is a privileged scaffold in …
reports indicated its crucial importance for biological activity; thus, it is a privileged scaffold in …
Predicting target–ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery
Drug Discovery is an active research area that demands great investments and generates
low returns due to its inherent complexity and great costs. To identify potential therapeutic …
low returns due to its inherent complexity and great costs. To identify potential therapeutic …
Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver (I) complexes
In this study, a series of N-functionalized benzimidazole silver (I) complexes were prepared
and characterized by FT-IR, 1H, 13C {1H} NMR spectroscopy, and elemental analysis …
and characterized by FT-IR, 1H, 13C {1H} NMR spectroscopy, and elemental analysis …
Nitrogen Enriched Tröger's Base Polymers of Intrinsic Microporosity for Heterogeneous Catalysis
N Hawkins, AR Antonangelo, M Wood… - ACS Applied Polymer …, 2024 - ACS Publications
Heterogeneous catalysis is significantly enhanced by the use of highly porous polymers with
specific functionalities, such as basic groups, which accelerate reaction rates. Polymers of …
specific functionalities, such as basic groups, which accelerate reaction rates. Polymers of …
Highly Active Small Aminated Quinolinequinones against Drug-Resistant Staphylococcus aureus and Candida albicans
Two subseries of aminated quinolinequinones (AQQs, AQQ1–16) containing electron-
withdrawing group (EWG) or electron-donating group (EDG) in aryl amine moiety were …
withdrawing group (EWG) or electron-donating group (EDG) in aryl amine moiety were …