Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is
characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of …

Glioblastoma multiforme (GBM) is a malignant tumor within the brain. Generally classified as
primary and secondary with several different subtypes, ample molecular biomarkers have …

As the most dangerous tumors, brain tumors are usually treated with surgical removal,
radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas …

Adeno-associated viral vectors (AAVs) have demonstrated potential in applications for
neurologic disorders, and the discovery that some AAVs can cross the blood-brain barrier …

Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery
systems in gene therapy for inherited monogenetic diseases. First market approvals …

Simple Summary Cancer is a complicated disease that has a significant characteristic of
evading cell death (apoptosis). The induction of apoptosis in cancerous cells seems a …

Adeno-associated virus (AAV) vector, an excellent gene therapy vector, has been widely
used in the treatment of various central nervous system (CNS) diseases. Due to the …

Simple Summary This review provides a roadmap to develop safe and effective OV-based
future therapeutics by using several novel synthetic and system biology strategies …

Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different
types of oncolytic viruses–adenoviruses, alphaviruses, herpes simplex viruses, Newcastle …

Abstract Adeno-associated virus (AAV)-PHP. B and AAV-PHP. eB (PHP. eB), a capsid
variant of AAV serotype 9, efficiently penetrates the mouse blood-brain barrier and …