BRAF inhibitor therapy may provide profound initial tumor regression in metastatic
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …

Renal cell carcinoma (RCC) comprises a diverse group of malignancies arising from the
nephron. The most prevalent type, clear cell renal cell carcinoma (ccRCC), is characterized …

Cell lines are key tools for preclinical cancer research, but it remains unclear how well they
represent patient tumor samples. Direct comparisons of tumor and cell line transcriptional …

There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is
associated with poor prognosis. The histone H3 lysine 36 methyltransferase SET-domain …

Background Renal cell carcinoma (RCC) is a heterogeneous disease comprising
histologically defined subtypes. For therapy selection, precise subtype identification and …

Genetic interactions mediate the emergence of phenotype from genotype. The systematic
survey of genetic interactions in yeast showed that genes operating in the same biological …

Immortal cancer cell lines (CCLs) are the most widely used system for investigating cancer
biology and for the preclinical development of oncology therapies. Pharmacogenomic and …

Cell lines are commonly used as cancer models. The tissue of origin provides context for
understanding biological mechanisms and predicting therapy response. We therefore …

We aimed to explain the role of mesenchymal stem cells (MSC-exosomes) on gene
expressions of epithelial to mesenchymal transition (EMT), angiogenesis, and apoptosis …